Tom Ryan / A5omic

Protocol Log / Week 1

Week 1: KSM-66 + Tongkat Ali

Research Note inconclusive · low confidence

QuestionIf I add ashwagandha and Tongkat Ali together for seven days, what happens to anxiety, calm, sleep, training drive, recovery, skin/appearance, and side effects?

Current ReadWeek 1 finished with 7/7 adherence, favorable calm on the scored days, no clear adverse response, and solid training performance even after poor sleep. The signal is still inconclusive: sleep, caffeine, training load, soreness, expectation effects, and normal appearance variance are large enough to explain most of the week.

1 benefit 1 negative 4 neutral 1 limit

Claim Ladder

  1. This does not directly measure cortisol, testosterone, or any internal mechanism.
  2. It tests whether a defined stack produces noticeable daily changes in calm, recovery, sleep, training drive, skin, or side effects.
  3. A promising week means repeat with tighter controls, not claim a biological mechanism.
  4. A bad week means stop, reduce, or redesign the protocol before layering anything else on top.
Evidence Review Why this question is testable
Randomized double-blind placebo-controlled trial / 2012 / used

A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults

Indian Journal of Psychological Medicine

This is the direct KSM-66-style stress/anxiety anchor that made 600 mg/day worth testing rather than guessing.

The trial ran 60 days in chronically stressed adults; a one-week personal log cannot infer the same effect.

Randomized double-blind placebo-controlled trial / 2021 / skimmed

A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males

PubMed

This is the 200 mg/day Tongkat Ali anchor and it intersects with training, which is one of the signals I can track.

The population was older men with androgen-deficiency symptoms over six months, so it does not justify testosterone claims here.

Intervention Take KSM-66 ashwagandha 600 mg/day and Tongkat Ali 200 mg/day with food, then log daily body signals.

HypothesisThe stack may improve perceived calm, stress tolerance, sleep quality, or training drive, but one week is short and the signal can easily be swamped by training load, caffeine, sleep debt, placebo, and normal mood variation.

Completion CriteriaAt least 6 of 7 days with both supplements taken with food and a complete daily observation record.

Signal Board Benefits, negatives, and limits
benefit Adherence
7/7 recorded days hit

Every planned observation day was logged with both supplements taken.

negative Sleep
down Fri/Sat

Sleep was useful early, then worsened on the final two days. That argues against a clean sleep-benefit read this week.

neutral Calm / anxiety
calm 8-9/10

The scored days were favorable, but expectation effects, caffeine, training load, and normal mood variance are too large to interpret causally.

neutral Home measures
2 captured days

Thursday and Saturday added private home-lab baselines. Exact values stay internal; this is baseline material rather than a trend.

neutral Skin
Acne noise + vascularity

Small acne noise appeared earlier, then Saturday added a vascularity/vein-visibility note. Appearance signals are too confounded to assign cause.

neutral Training
solid final gym session

Training drive and performance were present, including a solid final biceps/triceps session, but hard training and soreness are major competing explanations.

limitation Confounders
sleep + training + caffeine

Poor sleep, high training load, caffeine/pre-workout, soreness, and expectation effects are strong enough to dominate the result.

Charts Daily signal view

Adherence

1 Sun
1 Mon
1 Tue
1 Wed
1 Thu
1 Fri
1 Sat

Calm Score

Sun
Mon
8/10 Tue
8/10 Wed
9/10 Thu
9/10 Fri
9/10 Sat

Energy Score

Sun
Mon
9/10 Tue
7/10 Wed
8/10 Thu
8/10 Fri
8/10 Sat

Mood Score

Sun
Mon
9/10 Tue
9/10 Wed
8/10 Thu
8/10 Fri
8/10 Sat

Sleep Logged

1 Sun
1 Mon
1 Tue
1 Wed
1 Thu
1 Fri
1 Sat

Home Lab Logged

0 Sun
0 Mon
0 Tue
0 Wed
1 Thu
0 Fri
1 Sat

Side-Effect Clear

1 Sun
1 Mon
1 Tue
1 Wed
1 Thu
1 Fri
1 Sat
Measurement Plan Supplement / Compound

Primary Markers

  • Dose and timing: KSM-66 600 mg, Tongkat Ali 200 mg, time taken, AM or PM, with food.
  • Anxiety / calm: anxiety 1-10, calm 1-10, irritability 1-10, notable stress events.
  • Side effects: GI changes, headache, jitteriness, fatigue, sleep disruption, appetite changes, rash/flush.

Secondary Markers

  • Sleep / recovery: sleep quality, wakeups, HRV/RHR if available, soreness, morning energy.
  • Home vitals / grip / peak flow: exact SpO2 and pulse, seated blood pressure and pulse, grip strength, peak flow, sleep heart-rate range, and sleep respiratory-rate range are captured privately; public output shows trend status only.
  • Training spillover: motivation, RPE, best set, new rep max, pump, endurance feel, unusual fatigue.
  • Skin / appearance: acne, redness, dryness, oiliness, puffiness, under-eye look, irritation if notable.

Controls

  • Do not start another new supplement during the week unless it is explicitly logged.
  • Flag caffeine timing, pre-workout, hard training, poor sleep, unusual stress, illness, or late meals before interpreting the signal.
  • Treat stress, drive, and recovery language as subjective targets, not measured outcomes.
Protocol Setup Materials and setup
ordered KSM-66 ashwagandha

600 mg/day supplement under test.

Ordered from Amazon late April.
ordered Tongkat Ali

200 mg/day supplement under test, Indonesian-sourced.

Ordered from Amazon late April.
owned Structured daily observation template

Capture dose timing, body signals, side effects, confounders, and notes in the same format each day.

Used for each daily log entry.

Prep Notes

  • Take both with food and log AM vs PM timing.
  • Keep caffeine and pre-workout timing visible because they can dominate anxiety and sleep signals.
  • For future experiments, identify required materials at least one week before the intended start date.

Daily Observations

7/7 days recorded · 100% protocol-hit rate

100%
Sun hit

Take KSM-66 600 mg + Tongkat Ali 200 mg with food.

dose, sleep, mood/anxiety, training, confounders, skin/appearance, side effects Dose hit. Mood: positive/stable subjective read; numeric scores not logged. Sleep: logged. Training: strength work logged. Skin: no major visible issue logged. Side effects: no clear issue logged. Confounders: caffeine/pre-workout, training load.
dosemoodtrainingskinside effectconfoundersleep
Mon hit

Take KSM-66 600 mg + Tongkat Ali 200 mg with food.

dose, sleep, mood/anxiety, training, confounders, skin/appearance, side effects Dose hit. Mood: subjective read logged. Sleep: logged. Training: strength work logged, failure work. Skin: small acne/appearance signal logged. Side effects: no clear issue logged. Confounders: caffeine/pre-workout, training load, stress.
dosesleepmoodtrainingskinside effectconfounder
Tue hit

Take KSM-66 600 mg + Tongkat Ali 200 mg with food.

dose, mood/anxiety, sleep, training, side effects, skin/appearance, confounders Dose hit. calm 8/10 (high), energy 9/10 (high), mood 9/10 (high), anxiety 2/10 (low). Sleep: sleep score 8/10, subjectively good. Training: strength work logged, failure work, fatigue/soreness signal. Skin: small acne/appearance signal logged. Side effects: no clear issue logged. Confounders: caffeine/pre-workout, training load, stress, sleep quality.
dosesleepmoodtrainingskinside effectconfounder
Wed hit

Take KSM-66 600 mg + Tongkat Ali 200 mg with food.

dose, mood/anxiety, sleep, side effects, training, confounders, skin/appearance Dose hit. calm 8/10 (high), energy 7/10 (moderate), mood 9/10 (high), anxiety 1/10 (low). Sleep: about 8h, sleep score 8/10, subjectively good, interruption noise. Training: run logged, strength work logged, fatigue/soreness signal. Skin: small acne/appearance signal logged. Side effects: no clear issue logged. Confounders: caffeine/pre-workout, training load, stress, meal timing.
dosesleepmoodtrainingskinside effectconfounder
Thu hit

Take KSM-66 600 mg + Tongkat Ali 200 mg with food.

dose, vitals/home measures, mood/anxiety, side effects, sleep, training, skin/appearance, confounders Dose hit. calm 9/10 (high), energy 8/10 (high), mood 8/10 (high), anxiety 1/10 (low). Sleep: about 8h. Training: run logged, strength work logged, fatigue/soreness signal. Skin: acne/appearance signal stable or improved. Side effects: no clear issue logged. Confounders: caffeine/pre-workout, training load, stress, meal timing.
dosevitalssleepmoodtrainingskinside effectconfounder
Fri hit

Take KSM-66 600 mg + Tongkat Ali 200 mg with food.

dose, mood/anxiety, sleep, training, skin/appearance, side effects, confounders Dose hit. calm 9/10 (high), energy 8/10 (high), mood 8/10 (high), anxiety 1/10 (low). Sleep: about 7h, worse than baseline. Training: run logged, no gym session. Skin: appearance check logged. Side effects: no clear issue logged. Confounders: training load, sleep quality, prior-day profile.
dosesleepmoodtrainingskinside effectconfounder
Sat hit

Take KSM-66 600 mg + Tongkat Ali 200 mg with food.

dose, vitals/home measures, sleep, mood/anxiety, training, side effects, confounders, skin/appearance Dose hit. calm 9/10 (high), energy 8/10 (high), mood 8/10 (high), anxiety 1/10 (low). Sleep: about 6.5h, worse than baseline. Training: strength work logged, body signal logged, fatigue/soreness signal. Appearance: vascularity/vein visibility noted. Side effects: no clear issue logged. Confounders: training load, sleep quality.
dosevitalssleepmoodtrainingskinside effectconfounder

Study Snapshot

Weekly test
KSM-66 + Tongkat Ashwagandha 600 mg/day + Tongkat Ali 200 mg/day.
Observations
7/7 complete Sunday through Saturday are captured.
Primary signal
Anxiety + recovery Subjective first; no causal claim from one week.
Current status
Inconclusive Adherence was clean; causal interpretation is not.
New marker
Home vitals + grip + peak flow Exact readings stay internal; public output uses capture status and trend direction.

Protocol Changes

  • Launch weekly public self-experiments.
  • Start with the late-April Amazon supplement additions: KSM-66 ashwagandha and Indonesian-sourced Tongkat Ali.
  • Track dose timing, intended signals, side effects, appearance notes, training spillover, and confounders.
  • Added daily home vitals, grip, and peak flow on Thursday as private raw measurements with public trend summaries.

Current Read

Week 1 is complete. The solid result is adherence: every planned observation was a hit. The scored days show favorable calm/anxiety, the final gym session was solid despite poor sleep, and Saturday added another private home-lab capture plus an appearance note: more visible vascularity.

That is not enough to call the stack helpful or harmful. The strongest signal is still the noise: poor sleep on the final stretch, caffeine/pre-workout, hard training, persistent soreness, expectation effects, and normal appearance variance could all move anxiety, appetite, sleep, soreness, fatigue, libido, pump, and skin.

Result Profile

Week 1 Verdict

Inconclusive, with useful baselines. The honest read is: clean adherence, favorable subjective calm on scored days, no clear adverse response, small acne noise, one vascularity note, solid training performance, useful private home-measure baselines, and too many confounders for a causal claim.

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