Tom Ryan / A5omic

Protocol / Queue

Experiment Queue

Upcoming experiments are screened before they become weekly tests. The queue favors mechanism-forward interventions with visible signals, useful negatives, clear stop criteria, and longer follow-up windows when one week is too short. Some tests push the edge of existing evidence; others are original n=1 protocols designed here.

Materials Pipeline

Item Status Timing Candidate Note
Red/NIR light panel ordered Ordered May 5 Photobiomodulation recovery / face scan 660nm + 850nm panel bought for the photobiomodulation pilot.
Eye protection ordered Ordered with panel Photobiomodulation recovery / face scan Use goggles/eyes closed, especially when NIR is active.
Phone tripod or fixed photo mark ordered Ordered May 5 Photobiomodulation recovery / face scan Needed for consistent face scans and before/after comparison.
Grip dynamometer ordered Ordered May 5 Photobiomodulation recovery / face scan Optional recovery/performance marker if it arrives in time.
Reaction-time app owned Ready Photobiomodulation recovery / face scan Use the same device, app, and time window for repeatability.
Sauna or controlled heat access ordered Ordered May 5 Heat-stress dose response Heat source/access purchased or being set up before the first session.
Electrolytes ordered Ordered May 5 Heat-stress dose response Only useful if heat sessions are long enough to create noticeable sweat loss.
Thermometer ordered Ordered May 5 Heat-stress dose response Makes heat dose less hand-wavy if using a bath or room setup.
Hard chewing gum ordered Ordered May 5 Hard gum jaw/structure block Needs known hardness and conservative dosing.
Phone tripod or fixed photo mark ordered Ordered May 5 Hard gum jaw/structure block Makes before/after photos more comparable.
Creatine monohydrate ordered Ordered May 5 Creatine saturation map Plain monohydrate; no blended stimulant formula.
Consistent scoop or scale ordered Ordered May 5 Creatine saturation map Useful for keeping dose boring and repeatable.
Upper-arm BP cuff ordered Ordered May 5 Heat plus cognition recovery curve Needed for pre/post pulse and BP response.
Grip dynamometer ordered Ordered May 5 Heat plus cognition recovery curve Gives a quick nervous-system/performance marker.
Reaction-time app owned Ready Heat plus cognition recovery curve Use the same phone/app/time window for every session.
Hard chewing gum ordered Ordered May 5 Face structure stack Needs conservative dose and known hardness.
Phone tripod or fixed photo mark ordered Ordered May 5 Face structure stack Makes appearance scans comparable.
Soft measuring tape ordered Ordered May 5 Face structure stack Useful for neck/waist/body-state context.
Plain moisturizer or barrier product ordered Ordered May 5 Half-face skin barrier assay Only one boring intervention at a time.
Phone tripod or fixed photo mark ordered Ordered May 5 Half-face skin barrier assay Controlled lighting matters more than fancy products.
Sleep mask ordered Ordered May 5 Protected sleep window Only if light leakage is actually a problem.
Room thermometer ordered Ordered May 5 Protected sleep window Useful if temperature becomes a suspected confounder.
Candidate / Light exposure / recovery / appearance / original-protocol / candidate

Photobiomodulation recovery / face scan

Question: Does a controlled red/NIR light dose change skin appearance, soreness, grip, reaction time, sleep, or next-day training readiness?

Mechanism: Red and near-infrared light are marketed for skin and recovery, but the useful n=1 question is not whether the category works. It is whether a consistent dose creates any visible face-scan, soreness, nervous-system, or training-readiness signal in this body.

Horizon: 7-day pilot, 14-day follow-up if signal appears

Daily target: Panel minutes, distance, body area, goggles/eye protection, controlled face photo, skin score, soreness, grip, reaction time, sleep quality, training readiness, headache/eye strain/irritation.

Markers

  • light dose
  • distance/area
  • controlled photos
  • skin score
  • soreness
  • grip
  • reaction time
  • sleep
  • symptoms

Evidence Hooks

  • photobiomodulation exercise recovery delayed onset muscle soreness randomized trial
  • photobiomodulation skin red light near infrared systematic review
  • photobiomodulation sports performance recovery review

Stop Criteria

  • Eye discomfort, headache, skin irritation, unusual flushing, dizziness, sleep disruption, or any symptom that persists after stopping the session.

Rationale: This is a stronger public hook than generic sauna or creatine: a device-based intervention, visible scan surface, recovery markers, graphs, and clear uncertainty.

Candidate / Thermal stress / cardiovascular / literature-edge / candidate

Heat-stress dose response

Question: Does controlled heat exposure create a measurable recovery, sleep, or resting-heart-rate signal without hurting training quality?

Mechanism: Passive heat stress pushes cardiovascular strain, sweating, vasodilation, perceived stress tolerance, and possibly next-day recovery. The useful question is dose-response, not heroic tolerance.

Horizon: 7-day block, 30-day follow-up if signal appears

Daily target: Heat exposure minutes, temperature if known, peak/average HR if available, perceived heat stress 1-10, hydration/sodium, sleep quality, morning energy, training response.

Markers

  • heat dose
  • peak HR
  • RHR/HRV if available
  • sleep quality
  • training response
  • hydration
  • symptoms

Evidence Hooks

  • sauna bathing cardiovascular mortality cohort
  • passive heat therapy cardiovascular adaptation review
  • heat exposure heart rate variability sleep recovery

Stop Criteria

  • Dizziness, nausea, near-faint feeling, chest pain, unusual palpitations, severe headache, or heat symptoms that persist after cooling down.

Rationale: More interesting than a generic sleep week because it creates an acute physiological load with measurable next-day signals and clear safety boundaries.

Candidate / Looks / structure / original-protocol / candidate

Hard gum jaw/structure block

Question: Does a bounded hard-gum protocol create any visible jaw/neck signal without jaw pain, headaches, or tooth sensitivity?

Mechanism: Repeated chewing loads the masseter and temporalis. The experiment is whether a conservative dose creates any visible or subjective signal before irritation shows up.

Horizon: 14-day block, photo review at 30 days

Daily target: Chewing minutes, side balance, jaw soreness, clicking, headache, tooth sensitivity, controlled photo notes.

Markers

  • protocol dose
  • symmetry/photos
  • jaw/neck feel
  • visible signal
  • stop criteria

Evidence Hooks

  • masticatory muscle training chewing gum masseter hypertrophy
  • temporomandibular disorder chewing gum overuse

Stop Criteria

  • Jaw clicking with pain, tooth sensitivity, headache, bite change, facial pain, or soreness that carries into the next day.

Rationale: A popular appearance claim becomes more interesting when the dose, photos, symptoms, and stop criteria are explicit.

Candidate / Strength / hypertrophy / literature-edge / candidate

Train-to-failure bounded block

Question: What is the recovery cost of taking selected lifts to failure for three sets compared with normal training?

Mechanism: Training to failure increases local fatigue and recruitment, but may create enough recovery cost to reduce later work. The experiment measures the tradeoff, not just the pump.

Horizon: 7-day acute fatigue block, repeat only if recovery is clean

Daily target: Exercise, load, reps, RPE, failure yes/no, soreness next morning, joint signal, sleep/recovery.

Markers

  • sets/reps/load
  • RPE
  • rep PRs
  • DOMS curve
  • joint flags
  • next-session performance

Evidence Hooks

  • resistance training to failure hypertrophy strength meta analysis
  • training to failure recovery soreness fatigue

Stop Criteria

  • Sharp joint pain, form breakdown, persistent soreness that blocks the next session, or sleep/recovery crash for two days.

Rationale: More intensity is not automatically better; this measures the recovery cost before treating failure as a default.

Longer candidate / Supplement / performance / literature-edge / candidate

Creatine saturation map

Question: Does creatine create a visible strength, bodyweight, pump, sprint, or recovery signal when tracked daily instead of treated as background noise?

Mechanism: Creatine changes phosphocreatine availability and usually shifts water/glycogen-related body mass. The interesting part is whether performance moves enough to matter for this body.

Horizon: 28-day block

Daily target: Dose, bodyweight, water intake, GI signal, best set on selected lifts, sprint or rowing benchmark if used, pump/fullness, sleep/recovery.

Markers

  • dose adherence
  • bodyweight trend
  • selected lift performance
  • short-burst performance
  • GI tolerance
  • appearance notes

Evidence Hooks

  • creatine monohydrate resistance training meta analysis
  • creatine body mass water retention performance review

Stop Criteria

  • GI distress, cramping, unusual water retention discomfort, or any signal strong enough to interfere with normal training.

Rationale: It is common, but a 28-day saturation map with performance and appearance markers is more useful than a casual supplement note.

Longer candidate / Mobility / hypertrophy / literature-edge / candidate

Loaded-stretch hypertrophy probe

Question: Can long-muscle-length loading improve range, soreness profile, pump, or visible muscle fullness without aggravating joints?

Mechanism: Loaded stretch and long-muscle-length training may create a different hypertrophy and flexibility signal than normal reps. The test is local adaptation versus irritation.

Horizon: 14-day block, 30-day tissue review

Daily target: Muscle group, load, stretch duration, pain 0-10, pump, soreness next morning, ROM photo or distance marker, next-session performance.

Markers

  • stretch dose
  • ROM marker
  • pain score
  • pump/fullness
  • DOMS curve
  • training carryover

Evidence Hooks

  • long muscle length resistance training hypertrophy systematic review
  • loaded stretching hypertrophy flexibility study

Stop Criteria

  • Sharp tendon/joint pain, numbness, strength drop, or soreness that worsens across consecutive days.

Rationale: This is a better science-forward body experiment than generic stretching because the dose, tissue response, and performance cost can be tracked.

Original candidate / Thermal stress / cognition / original-protocol / candidate

Heat plus cognition recovery curve

Question: After a controlled heat dose, how long does reaction time, grip, balance, mood, and perceived clarity take to return to baseline?

Mechanism: Heat is an acute physiological perturbation. The original part is the recovery-curve measurement: not just whether heat feels good, but how quickly the system re-stabilizes across cognitive and physical markers.

Horizon: 3-session pilot, then 7-day block if clean

Daily target: Pre-test reaction time, grip, balance, BP/pulse, heat dose, post-test at 10/30/60 minutes, symptoms, next-morning recovery.

Markers

  • reaction time
  • grip
  • balance
  • BP/pulse
  • heat dose
  • symptoms
  • next-day recovery

Evidence Hooks

  • heat exposure cognitive performance recovery
  • sauna heart rate recovery physiology
  • thermal stress reaction time study

Stop Criteria

  • Any dizziness, near-faint feeling, chest pain, unusual palpitations, confusion, severe headache, or symptoms that do not resolve after cooling down.

Rationale: This is closer to an original n=1 assay: the intervention is known, but the personal recovery curve is the object being measured.

Original candidate / Looks / posture / structure / original-protocol / candidate

Face structure stack

Question: If chewing dose, neck posture drills, nasal breathing during walks, and sodium/hydration notes are tracked together, does facial sharpness or jaw/neck presentation visibly change?

Mechanism: This is an appearance-system protocol rather than a single intervention: muscle tone, posture, inflammation/puffiness, hydration, and controlled photos are measured together to separate real signal from lighting and wishful thinking.

Horizon: 14-day block, 30-day photo review

Daily target: Chewing minutes, posture drill minutes, nasal-walk minutes, sodium/hydration note, skin/puffiness score, jaw/neck symptoms, controlled photo if scheduled.

Markers

  • chewing dose
  • posture dose
  • hydration/sodium
  • skin/puffiness
  • jaw/neck symptoms
  • controlled photos

Evidence Hooks

  • masticatory muscle training masseter hypertrophy
  • forward head posture neck exercise facial profile
  • facial puffiness sodium hydration

Stop Criteria

  • Jaw pain/clicking, tooth sensitivity, headache, neck pain, bite discomfort, or worsening tension that carries into the next day.

Rationale: This is one of the project-own protocols: not a copy of one paper, but a bounded appearance experiment with stop rules and controlled scans.

Original candidate / Skin / appearance / original-protocol / candidate

Half-face skin barrier assay

Question: Can a split-face routine show whether one simple skin intervention changes redness, acne, dryness, oiliness, or irritation compared with the untreated side?

Mechanism: The face is naturally noisy. A split-face design gives a built-in control, as long as the intervention is gentle and the photos/scoring stay consistent.

Horizon: 14-day block

Daily target: Apply intervention to assigned side only, log acne/redness/dryness/oiliness/irritation 0-3 per side, controlled photo every 3-4 days.

Markers

  • side-specific adherence
  • acne count
  • redness score
  • dryness/oiliness
  • irritation
  • controlled photos

Evidence Hooks

  • split face dermatology study design moisturizer barrier
  • skin barrier moisturizer randomized split face study

Stop Criteria

  • Burning, rash, swelling, worsening irritation, or any reaction that spreads beyond mild dryness/redness.

Rationale: This is a clean original design: simple, visual, low-cost, and easy to publish without overclaiming.

Control candidate / Sleep / recovery / control / candidate

Protected sleep window

Question: Does protecting a fixed sleep window move next-day mood, training quality, and wearable recovery more than supplements do?

Mechanism: Sleep is not the most provocative intervention, but it is the baseline control that explains or erases many other signals.

Horizon: 7-day control block

Daily target: Lights out target, caffeine cutoff, last meal time, sleep quality score, wakeups, HRV/RHR if available.

Markers

  • sleep opportunity
  • actual sleep
  • morning energy
  • training response
  • confounders

Evidence Hooks

  • sleep extension athletes performance recovery
  • sleep restriction mood anxiety HRV

Stop Criteria

  • None beyond normal sleep disruption; this is a control block, not a stressor.

Rationale: Useful as a calibration week, but not the front edge of the project.