Tom Ryan / A5omic

Protocol / Methodology

Methodology

This is a public engineering log about one body. The unit of work is a weekly test: define the target, record daily observations, look for body signals, and publish the verdict. Experiments can be health, performance, or appearance-adjacent; the interpretation stays disciplined.

What Gets Tracked

  • The weekly experiment target and whether it was hit each day.
  • Sleep duration, resting HR, HRV, and recovery estimates from wearables.
  • Mood, energy, anxiety, training quality, caffeine timing, and last meal timing.
  • Confounders: stress, illness, travel, injury, alcohol, late meals, and unusual workouts.
  • Experiment-specific measurement plans: supplement effects, skin changes, gym maxes, soreness, mobility, digestion, focus, or endurance output.
  • Unconventional experiments are allowed only when they are measurable, bounded, reversible, and tracked for downsides.
  • Materials, lead time, purchase status, and setup notes for experiments that require buying gear, supplements, tests, or tools.
  • Study origin: literature-edge, original protocol, or control block.
  • The weekly verdict: keep, modify, discard, or repeat with better controls.

Known Limits

  • n=1 data is not science. It is a disciplined personal log with obvious external validity limits.
  • Wearable sleep stages are noisy. HRV is useful, but single-day HRV is easy to over-interpret.
  • Experiments are constrained by real life: training, work stress, travel, social plans, illness, and imperfect adherence.
  • Training load, stress, illness, travel, caffeine, and regression to the mean can all masquerade as protocol effects.

Study Origin

Papers are guardrails, not a ceiling. Some experiments deliberately test the edge of published protocols. Others are original n=1 assays designed around a mechanism, a measurement surface, and stop criteria. The standard is not whether a perfect study already exists; the standard is whether the question can be bounded, measured, and interpreted honestly.

Privacy Boundary

The public log should still show metrics. The boundary is not "hide everything"; it is "publish experimental signal, keep medical-style raw readings private by default."

Public Footprint

  • Adherence: hit, partial, miss, and streak/completion rate.
  • Subjective scores: anxiety, calm, irritability, energy, mood, sleep, and soreness on 1-10 scales when logged.
  • Sleep: rounded duration, quality bucket, wakeup/interruption signal, and direction versus baseline.
  • Training: run/strength category, fatigue/soreness, new maxes when intentionally public, and performance direction.
  • Appearance and side effects: acne/skin/vascularity notes, side-effect status, and whether the signal improved, worsened, or stayed noisy.
  • Home lab: capture count plus trend or bucket summaries for BP, oxygen, grip, peak flow, sleep HR, and respiration.

Private By Default

  • Exact blood pressure, SpO2/pulse, grip, peak flow, sleep HR/respiration ranges, and similar medical-style readings.
  • Exact caffeine amount, exact training loads or paces, and messy raw symptom wording unless a value is deliberately chosen for publication.
  • Anything that feels more like a health record than an experiment signal.

Interpretation Standard

Each verdict separates observations, plausible explanations, confounders, and next actions. Single-day wearable movement is treated as weak evidence. A null result is allowed.

Marker library →

Medical Boundary

Nothing here is medical advice. The artifact is the reasoning trail, not a prescription. Any risky or clinical intervention belongs with a clinician, not a blog cadence.